What we are looking for
AION Labs the Israel-based alliance of AstraZeneca, Merck, Pfizer, Teva, Israel Biotech Fund and Amazon Web Services (AWS), powered by BioMed X is supporting the establishment of a new, fully funded startup company in the field of:
Prediction of clinical trial outcome in biomarker-stratified cancer patient populations
If you hold a PhD or master’s degree with an outstanding track record or strong interest in the fields of computational biology, bioinformatics, data sciences, we invite you to apply with a project proposal for a position in our new startup team.
Each AION Labs startup team is sponsored by several industry-leading partners and supported by the Israel Innovation Authority. The sponsors of this call for application are AstraZeneca, Merck, Pfizer, and Teva, with close support from AWS.
Early oncology clinical trials typically have a single study arm with toxicity and efficacy related primary endpoints. The arm is typically small and only powered to test response rate against an assumed response rate based on the literature.
In this challenge we are looking for a platform that will predict the outcome of a phase III randomized oncology clinical trial given a single arm early phase I/II data. The platform is expected to optimize the patient population for the phase III study by identifying biomarkers within the existing early data and considering the standard of care to maximize the likelihood of success.
The input to the platform will be early oncology clinical trials results (phase I/II) where a novel drug or drug combination was tested. For development purposes and proof of concept, data sets of results from control arms of multiple historic oncology clinical trials will be provided.
The expected output should be:
The platform is expected to allow the use of drug response biomarkers that are typically not measured in clinical care. Very original ideas which go far beyond the current state-of-the-art are particularly encouraged.
The group leader / startup founder position is intended to suit candidates who would like to develop themselves towards an entrepreneurship path, and who typically have a PhD plus four to eight years of additional research experience in academia and/or industry.
What we offer
There is flexibility over starting dates, but successful applicants are welcome to take up post in Israel starting February 1, 2023.
Application & Selection Process
About AION Labs
AION Labs is a first-of-its-kind alliance of AstraZeneca, Merck, Pfizer, Teva, the Israel Biotech Fund and Amazon Web Services (AWS) that have come together with one clear mission: to create and adopt groundbreaking new AI technologies that will transform the process of drug discovery and development in order to contribute to the health and well-being of all people world-wide.
Located within the Israeli biotech hotspot in Rehovot adjacent to Weizmann Institute for Sciences, AION Labs is a unique venture hub where brilliant innovators convene from around the world to solve the biggest R&D challenges guided by years of accumulated know-how, data and experience in pharma. The lab leverages its partners’ wealth of knowledge and a new multidisciplinary mindset with the ingenuity, agility and innovative power of Israel’s start-up ecosystem, to develop strong companies with clear long-term strategies, that will pave the way to the future of healthcare. AION Labs cultivates innovation from within; its unique venture creation process bridges the gap between outstanding academic research in the field of AI and the biggest R&D needs in the discovery and development of new medicines for the benefit of patients.
About BioMed X
BioMed X is an independent research institute located on the campus of the University of Heidelberg in Germany, with a world-wide network of partner locations. Together with our partners, we identify big biomedical research challenges and provide creative solutions by combining global crowdsourcing with local incubation of the world’s brightest early-career research talents. Each of the highly diverse research teams at BioMed X has access to state-of-the-art research infrastructure and is continuously guided by experienced mentors from academia and industry. At BioMed X, we combine the best of two worlds – academia and industry – and enable breakthrough innovation by making biomedical research more efficient, more agile, and more fun.
4 Oppenheimer St.
Rehovot Science Park
Phone: +972 50-831-8505